【藥品性質提示】 根據 2019 AGS Beers Criteria，本藥品為【潛在不適當用藥 (PIM)】，不建議用於老年人。

一代抗組織胺 Motion sickness, relief of allergic states, postoperative vomiting, drug induced nausea and vomiting

First generation Histamine H₁ Antagonist
Meclizine has CNS depressant, anticholinergic, antiemetic, antispasmodic, and local anesthetic effects in addition to antihistaminic activity. The drug depresses labyrinth excitability and conduction in vestibular-cerebellar pathways. The antiemetic and antimotion-sickness actions of meclizine result, at least in part, from its central anticholinergic and CNS depressant properties.

Onset: 1 hour
Duration: prolonged, with effects persisting 8–24 hours following administration of a single oral dose
Plasma half-life: 6 hours
Excretion: feces(unchanged); urine(norchlorcyclizine)

Hypersensitivity to meclizine

B

No data available.

Dry mouth, dizziness, blurred vision, fatigue

Motion sickness: 25-50 mg should be taken 1 hour before travel
Severe nausea and vomiting: 25-50 mg BID or TID

Children 6-12 y/o: half the adult dose