Postpartum hemorrhage, associated with uterine atony or subinvolution after delivery of the placenta.
Uterine hemorrhage, during second stage of labor after delivery of the anterior shoulder.

Increases the tone, rate and amplitude of contractions on the smooth muscles of the uterus, producing sustained contractions which shortens the third stage of labor and reduces blood loss.(UTD)

Absorption:
Bioavailability: 78%
Distribution:
Vd: 56.1 L +/- 17 L
Metabolism:
Hepatic; first-pass metabolism
Elimination Half Life:
3.39 h

hypersensitivity to methylergonovine products
hypertension
pregnancy
toxemia

C (FDA)

Milk effects are possible.(MDX)

Common:
Cardiovascular: Hypertension
Neurologic: Headache
Serious:
Cardiovascular: Myocardial infarction
Neurologic: Seizure.

Prevention of hemorrhage:
IM, IV: 0.2 mg after delivery of anterior shoulder, after delivery of placenta, or during puerperium; may be repeated every 2 to 4 hours as needed.

safety and efficacy not established in pediatric patients