Vitamin B12 deficiency

Vitamin, Water Soluble

Absorption:Variable from the terminal ileum; requires the presence of calcium and gastric “intrinsic factor” to transfer the compound across the intestinal mucosa.
Distribution: Principally stored in the liver and bone marrow, also stored in the kidneys and adrenals.
Metabolism: Converted in tissues to active coenzymes, methylcobalamin and deoxyadenosylcobalamin; undergoes some enterohepatic recycling.
Excretion: Urine (50% to 98%, unchanged drug)

Hypersensitivity to cyanocobalamin (vitamin B12), cobalt, or any component of the formulation

Dermatologic: Pruritus, skin rash (transient), urticaria
Gastrointestinal: Diarrhea, dyspepsia, glossitis, nausea, sore throat, vomiting

500 to 1,000 mcg orally once daily.

There are no dosage adjustments provided in the manufacturer’s labeling.

There are no dosage adjustments provided in the manufacturer’s labeling.