治療注意力不足過動症。

Central Nervous System Stimulant

Onset of action: Children:60 to 180 minutes.
Maximum effect: within 4 to 7 hours.
Duration of action: 2 to 8 hours.
Protein binding: 10% to 33%.
Bioavailability: 105% (49% to 168%) in children and 101% (85% to 152%) in adults (relative to IR oral product).
Time to peak: Children: 4.7 hours (range: 1.3 to 8.2 hours).
Excretion: Urine (78% to 97% as metabolites and unchanged drug); Feces (1% to 3%).

Hypersensitivity (eg, angioedema, anaphylaxis) to methylphenidate or any component of the formulation; use during or within 14 days following MAOI therapy.

Methylphenidate is present in breast milk.

>10%: decreased appetite (2% to 26%), nausea (2% to 13%), xerostomia (3% to 14%), headache (2% to 22%), insomnia (2% to 33%), irritability (2% to 11%).
1% to 10%: increased blood pressure (≧2%), increased diastolic blood pressure (7%), palpitations (3%), tachycardia (5%), excoriation of skin (4%), hyperhidrosis (5%), skin rash (2%), decreased libido (2%), weight loss (2% to 9%), abdominal pain (5% to 7%), anorexia (2% to 9%), constipation (1%), diarrhea (4%), motion sickness (2%), upper abdominal pain (4% to 9%), vomiting (2% to 10%), bruise (3%), aggressive behavior (2%), agitation (2%), anxiety (8%), depressed mood (4%), depression (2%), dizziness (2% to 7%), fatigue (3%), hypertonia (2%), jitteriness (4%), lack of emotion (2%), nervousness (3%), psychomotor agitation (5%), restlessness (3%), tremor (3%), vertigo (2%), back pain (3%), blurred vision (2%), eye pain (2%), cough (2%), nasopharyngitis (3%), streptococcal pharyngitis (3%), upper respiratory tract infection (2%), fever (2%).

Attention-deficit/hyperactivity disorder: once daily about 20 minutes after breakfast.