降血脂 (statin) Hyperlipidemia, Primary and secondary prevention of coronary events

Mevalotin competitively inhibit HMG-CoA reductase activity, it markedly reduce plasma concentration of LDL and total CHOL and to a lesser extent Apo-B and triglyceride and increase levels of HDL cholesterol.

Average oral absorption: 34%, absolute bioavailability : 17% ; extensive first-pass metabolism; Plasma protein binding : ∼50%; Elimination half-life: pravastatin sodium plus metabolites: 77 h hrs; Excretion:∼ 20% in urine and 70% in feces

Hypersensitivity to any component of this medication; Active liver disease or unexplained, persistent elevations of serum transaminases; Pregnancy and Lactation

X

Avoided.

Diarrhea, nausea, vomiting, flatulence, headache, weary, heartburn

Adults: 40 mg PO once daily. Children( 8-13 yrs): 20 mg PO once daily. May be taken with or without food at anytime of the day; when given with a bile-acid-binding resin (eg, cholestyramine, colestipol) give pravastatin either at least 1 hr before or 4 hr after the resin