高血壓 (Beta-blocker) Hypertension, angina pectoris.

The principal physiologic action of atenolol is to competitively block adrenergic stimulation of β-adrenergic receptors within the myocardium and within vascular smooth muscle.

Atenolol is rapidly but incompletely absorbed from the GI tract. Only about 50–60% of an oral dose of atenolol is absorbed. The effect of atenolol on heart rate usually has an onset of 1 hour, peaks at 2–4 hours, and persists for 24 hours following oral administration of the drug. Approximately 6–16% of atenolol is bound to plasma protein. Approximately 40–50% of an oral dose of the drug is excreted in urine unchanged. The remainder is excreted unchanged in feces, principally as unabsorbed drug. About 1–12% of atenolol is reportedly removed by hemodialysis. In patients with normal renal function, atenolol has a plasma half-life(t?) of 6–7 hours.

Sinus bradycardia, cardiac shock, symptomatic CHF

D

Probably safe, the milk/plasma ratios have varied from 2.9-3.6, an accumulation in the milk has been reported. The infant should be observed for signs of β-blockade, and mother with any degree of renal insufficiency should not feed infants.

Cold extremeties, muscular fatigue.

50-100mg QD.