Ambroxol is an active N-desmethyl metabolite of the mucolytic bromhexine. Ambroxol is used as an expectorant and mucolytic in the treatment of pulmonary disorders such as bronchitis and pulmonary infections to facilitate the removal of secretions from the lungs.
藥動學
Absorption: Rapid and complete; Bioavailability: 70% to 80%; Metabolism: Extensive hepatic metabolism; Excretion: Urine (90%; <10% as unchanged drug)
禁忌症
Hypersensitivity to ambroxol or components.
懷孕分類
B; Avoid use in the first trimester
哺乳分類
Ambroxol is excreted in breast milk. Breast-feeding is not recommended.
副作用
Dry mouth, diarrhea, constipation, nausea and vomiting, and sialorrhea , rash and contact dermatitis.
劑量和給藥方法
Adults: daily dose of 30 mg (one Ambroxol tablet ) to 120 mg (4 Ambroxol tablets) taken in 2 to 3 divided doses.
小兒調整劑量
Children up to 2 years: half a teaspoonful Ambroxol syrup twice daily; Children 2 - 5 years: half a teaspoonful Ambroxol syrup 3 times daily; Children over 5 years: One teaspoonful Ambroxol syrup 2-3 times daily.