【藥品性質提示】 根據 2019 AGS Beers Criteria，本藥品為【潛在不適當用藥 (PIM)】，用於老年人時須謹慎使用(監測血鈉值)。 #特殊劑型：不建議磨粉、管灌藥品

高血壓 (diuretics) 治療心衰竭 Edema (Congestive heart failure); Hypertension

Diuretic effect is localized at the proximal segment of the distal tubule of the nephron; it does not appear to have significant effect on glomerular filtration rate nor renal blood flow; like other diuretics, it enhances sodium, chloride, and water excretion by interfering with the transport of sodium ions across the renal tubular epithelium.

Absorption: Rapid and complete
Distribution: Vd 25 L; Protein binding 71-79%
Metabolism: Extensively hepatic
Excretion: Urine

1. Hypersensitivity to indapamide or any component of the formulation or sulfonamide-derived drugs
2. Anuria

B (FDA)

Infant risk cannot be ruled out.

Hypokalemia, Cramp, Asthenia, Dizziness, Headache, Lethargy, Numbness, Fatigue, Malaise, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Agranulocytosis, Aplastic anemia, Hepatitis, Anaphylaxis

Edema:
Initial 2.5 mg daily; if inadequate response after 1 week, may increase dose to 5 mg daily
Hypertension:
Initial 1.25 mg daily; if inadequate response, may increase dose once every 4 weeks to 2.5 mg daily and then to 5 mg daily if needed