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藥碼
NAT03
藥名
Testosterone 鼻凝膠
英文商品名
NaTESTo 鼻凝膠 11 mg/dose
中文商品名
耐他妥 鼻內凝膠劑
螢幕名
NaTESTO鼻凝膠 11 mg/Dose 5.5 mg/次
劑型
Gel
規格
Natesto (testosterone) nasal gel is available as a metered dose pump containing 11 grams of gel dispensed as 60 metered pump actuations. One pump actuation delivers 5.5 mg of testosterone in 0.122 grams of gel.
成分
藥理分類
Hormones & Synthetic substitutes- Androgens
健保碼
ATC碼
G03BA
藥品圖片
外觀圖片
適應症
【藥品訊息】
NaTESTO鼻凝膠 衛教單張

Hypogonadism, hypogonadotropic (congenital or acquired): Gonadotropin or luteinizing hormone-releasing hormone deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.
Hypogonadism, primary (congenital or acquired): Treatment of testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter syndrome, chemotherapy, or toxic damage from alcohol or heavy metals.
藥理
Androgen
藥動學
  • Absorption
    Natesto delivers physiologic amounts of testosterone, producing circulating concentrations that approximate normal testosterone concentrations (i.e., 300 to 1,050 ng/dL) seen in healthy men. The maximum concentration for Natesto is achieved within approximately 40 minutes of administration and has a half-life ranging from 10 to 100 minutes.
  • Distribution
    Circulating testosterone is primarily bound in the serum to sex hormone-binding globulin (SHBG) and albumin. Approximately 40% of testosterone in plasma is bound to SHBG, 2% remains unbound (free), and the rest is loosely bound to albumin and other proteins.
  • Metabolism
    Testosterone is metabolized to various 17-keto steroids through 2 different pathways. The major active metabolites of testosterone are estradiol and dihydrotestosterone (DHT).
    DHT concentrations increased in parallel with testosterone concentrations during Natesto treatment. After 90 days of treatment, the mean DHT/testosterone ratio was 0.09 which was within the normal range.
  • Excretion
    About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6% of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver.
    • 禁忌症
    Natesto is contraindicated in men with carcinoma of the breast or known or suspected carcinoma of the prostate.
    懷孕分類
    Natesto is contraindicated in women who are or who may become pregnant, or who are breast- feeding. Natesto may cause fetal harm when administered to a pregnant woman.
    哺乳分類
    Natesto may cause serious adverse reactions in nursing infants. Exposure of a fetus or nursing infant to androgens may result in varying degrees of virilization.
    副作用
  • Nasal adverse reactions：
    nasopharyngitis, rhinorrhea, epistaxis, nasal discomfort, parosmia, nasal scab, upper respiratory infection, nasal dryness, and nasal congestion.
  • Potential Adverse Reactions With Androgens：
    Changes in urinary habits such as increased urination at night, trouble starting your urine stream, passing urine many times during the day, having an urge that you have to go to the bathroom right away, having urine accident, being unable to pass urine, and having a weak urine flow.Breathing disturbances, including those associated with sleep, or excessive daytime sleepiness.Too frequent or persistent erections of the penis.Nausea, vomiting, changes in skin color, or ankle swelling.
    • 劑量和給藥方法
  • The recommended dose of Natesto is 11 mg of testosterone (2 pump actuations; 1 actuation per nostril) administered intranasally three times daily for a total daily dose of 33 mg.
  • Serum total testosterone concentrations should be checked periodically, starting as soon as one month after initiating treatment with Natesto. When the total testosterone concentration consistently exceeds 1050 ng/dL, therapy with Natesto should be discontinued.
  • If the total testosterone concentration is consistently below 300 ng/dL, an alternative treatment should be considered.
    • 小兒調整劑量
    腎功能調整劑量
    肝功能調整劑量
    安定性
    Store at 20°C to 25°C. Excursions are permitted to 15°C to 30°C.
    藥袋資訊
    臨床用途
    睪固酮補充
    主要副作用
    鼻部不適、鼻分泌物變色、鼻竇充血、結痂、痤瘡、體重增加
    泡製方法
    儲存方式
    請置於 15-30℃ 乾燥處儲存，每次劑量5.5mg，每劑(Dose)左右鼻孔各按一次。
    注意事項
    其他說明
    藥局 P1 | 藥庫 外用/水D21
    藥品外觀
    顏色
    形狀
    剝痕
    標記1
    標記2
    其他
    健保藥價
    0
    自費價
    1980
    仿單
    資料庫
    健保給付規定