【藥品性質提示】 根據 2019 AGS Beers Criteria，本藥品為【潛在不適當用藥 (PIM)】，不建議用於有骨折風險之老年人(除非用於癲癇、調節情緒)；腎功能不佳 (CrCl<60mL/min) 須降低劑量。

治療神經痛、癲癇 Postherpetic neuralgia; Seizures, focal (partial) onset
#仿單變更2022

The potential advantage of gabapentin over other antiepileptic agents is its apparent low order of toxicity.

The drug is not protein bound and does not appear to be metabolized; all of a dose is excreted unchanged in the urine. The terminal elimination half-life is 5 to 7 hours.

Hypersensitivity to Gabapentin; Pancreatitis

C

Gabapentin is distributed into milk following oral administration; the drug should be administered to nursing women only if the potential benefits justify the risk to the infant.

Common:
Peripheral edema, myalgia, somnolence, fatigue, dizziness, ataxia, nystagmus, weight gain, skin rash, blurred vision, diplopia, mood changes, tremor, hyperactive behavior
Significant:
1. CNS and respiratory depression: most cases occur with concomitant use of CNS depressants (especially opioids) in the setting of underlying respiratory impairment, renal impairment, or in older patients <20220218>
2. Neuropsychiatric effects: occurred in pediatric patients (3-12 y/o) with epilepsy, including emotional lability, hostility, changes in behavior, and hyperkinetic muscle activity

Postherpetic neuralgia:
900-1800 mg/day in 3 divided doses.
Seizures, focal (partial) onset:
Initial 300 mg 3 times daily; increase dose up to 900-1800 mg/day in 3 divided doses based on response and tolerability (doses up to 2.4 g/day and 3.6 g/day have been tolerated in long-term and short-term clinical studies, respectively)

For children age 3-12
1. Initial 10-15 mg/kg/day in 3 divided doses, titrate upward over 3 days
2. For children over 5 y/o: Maximum dose 25-35mg/kg/day
3. For children under 5 y/o: Maximum dose 40mg/kg/day

1. Crcl ≥80 mL/min: 900-1,800mg daily
2. Crcl 50-79 mL/min: 600-1,800mg daily
3. Crcl 30-49 mL/min: 300-900mg daily
4. Crcl 15-29 mL/min: 150-600mg daily
5. Crcl <15 mL/min: 150-300mg daily
6. Hemodialysis: Initial 300-400mg loading dose, follow with 200-300mg Gabapentin after hemodialysis

There are no dosage adjustments provided in the manufacturer's labeling; however, gabapentin is not hepatically metabolized.