【藥品訊息】 Nicotinell 咀嚼錠 衛教單張 #特殊劑型：不建議磨粉、管灌藥品

Nicotine replacement therapy is used as an adjunct to smoking cessation programs.

Patches are preferred for maintenance therapy during smoking cessation programs. Gum or nasal spray may be useful for intermittent treatment or for patients allergic to the patches.

Nicotine and its metabolites are rapidly excreted via the kidneys; renal clearance is pH-dependent. The elimination half-life of nicotine following transdermal administration is 4 hours.

Allergy to nicotine or any component of a nicotine delivery system; patients with life-threatening arrhythmias; patients with severe or worsening angina pectoris; use in patients during the immediate post-myocardial infarction period

D

Nicotine is excreted into breast milk, with the breast milk to plasma ratio of nicotine averaging 2.9.

Gastrointestinal effects include: decreased lower esophageal sphincter pressure, diarrhea, dry mouth, dyspepsia, gastrointestinal discomfort, hiccups and nausea. Adverse respiratory effects of nicotine include: bronchitis, coughing, throat irritation, and rhinitis. Reported cardiac effects are chest pain, hypertension, and tachycardia.

light smokers (less than 25 cigarettes per day), 1 piece of 2 mg gum every 1-2 hr for weeks 1-6, 1 piece of 2 mg gum every 2-4 hr for weeks 7-9, 1 piece of 2 mg gum every 4-8 hr for weeks 10-12.