【藥品庫存】 藥品安全警訊 (藥品回收)：本品因食藥署接獲不良品通報 (藥品卡鐵絲)，公告回收批號：FR3135、FT2343。院內目前使用的非回收批號。更新日期：2023/1/9。

治療心絞痛 高血壓 (CCB) Amlodipine is effective as once daily monotherapy in hypertension and angina pectoris.

Amilo (Amlodipine besylate) is a long-acting dihydropyridine calcium channel blocker that exerts its effect by blocking the transmembrane influx of calcium ions into cardiac and vascular smooth muscles. It also reduces peripheral vascular resistance and lowers blood pressure by causing a direct vasodilation in the peripheral arteries of the vascular smooth muscle. Its therapeutic effect on vasospastic angina is through inhibition of coronary spasm.

Amilo (Amlodipine besylate) is well absorbed with onset of action about 30-50 mins and peak blood levels between 6-12 hrs. Bioavailability is 64~90%. Duration of action is 24 hours. Protein binding is 93%.The volume of distribution is approximately 21 L/kg. Amlodipine is extensively metabolized by the liver to inactive metabolites with 10% of the parent compound and 60% of metabolites excreted in the urine.

Patient with hypersensitivity to amlodipine or symptomatic hypotension (systolic pressure < 90 mmHg), or patient with advanced aortic stenosis.

C

Infant risk cannot be ruled out.

Dose related peripheral edema; headache, flushing, palpitations and GI disturbances.

5 to 10mg QD. Dose reductions may be indicated in the elderly or those with hepatic failure, but are not necessary in renal impairment.

are not necessary in renal impairment.