Diabetic ketoacidosis or hyperosmolar hyperglycemic state, fluid management (off-label use): Initial fluid management:IV: 15 to 20 mL/kg/hour for 1 to 2 hours (usual dose: 1 to 1.5 L/hour). Hypercalcemia, volume replacement (off-label use): Initial: 1 to 2 L bolus (optional), followed by 150 to 300 mL/hour for 24 to 48 hours or until euvolemic. Septic shock or sepsis-induced hypoperfusion, fluid resuscitation (off-label use): Initial resuscitation: Minimum of 30 mL/kg to be given within the first 3 hours for shock or hypoperfusion.