1. Granulomatosis with polyangiitis, Eosinophilic.
2. Severe asthma, Add-on maintenance in patients with eosinophilic phenotype.

Interleukin-5 Antagonist Monoclonal Antibody
Mepolizumab is an interleukin-5 (IL-5) antagonist monoclonal antibody that reduces the production and survival of eosinophils

Absorption
Bioavailability, subQ: 80%
Distribution
Vd: 3.6 L
Metabolism
Body-wide proteolytic enzymes
Excretion
Total body clearance: 0.28 L/day
Half Life:
16 to 22 days

Hypersensitivity to mepolizumab or any ingredient in the product

Fetal risk cannot be ruled out (cross placenta)

Use of monoclonal antibodies for the treatment of asthma in lactating women may be considered when conventional therapies are insufficient; use of an agent other than mepolizumab may be preferred

Common
Dermatologic: Injection site reaction (Asthma, 8% ; Eosinophilic granulomatosis with polyangiitis, 15%)
Immunologic: Antibody development
Musculoskeletal: Backache
Neurologic: Headache
Other: Fatigue
Serious
Immunologic: Herpes zoster, Hypersensitivity reaction, Systemic

Eosinophilic granulomatosis with polyangiitis(EGPA), Hypereosinophilic syndrome(HES):
300 mg subQ (given as 3 separate 100-mg injections at least 5 cm apart in the upper arm, thigh, or abdomen) once every 4 weeks
Chronic rhinosinusitis with nasal polyps(CRSwNP):
100 mg subQ once every 4 weeks injected into the upper arm, thigh or abdomen.
<20230927>
Severe asthma, Add-on maintenance in patients with eosinophilic phenotype:
100 mg subQ once every 4 weeks injected into the upper arm, thigh or abdomen.

Severe asthma, Add-on maintenance in patients with eosinophilic phenotype:
(≥12 years old) 100 mg subQ once Q4W injected into the upper arm, thigh or abdomen.
(6-11 years old) 40 mg subQ once Q4W injected into the upper arm, thigh or abdomen.<20230927>

There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).

There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).

1. Store vial in below 25 degrees C. Do not freeze and protect from light.
2. After reconstitution, use immediately or store below 30 degrees C; do not freeze.
3. Discard if not used within 8 hours of reconstitution.