【缺藥訊息】 公告日期：2022/11/24。 缺藥品項：Olbetam 膠囊 250mg 缺藥原因：原廠因全球策略，停止該品項生產。 替代藥品：國內無同成份規格替代品。 配套措施：關檔停用，保留庫存給已開立慢箋。

降血脂 (其他) Type IIa (elevated plasma levels of cholesterol), IIb, III, IV (elevated plasma levels of triglycerides), V(elevated plasma levels of cholesterol and triglycerides) hyperlipoproteinemia.

Acipimox is a derivative of niacin. it inhibit hepatic triglyceride production and VLDL secretions, which leads indirectly to a modest reduction in LDL and increase in HDL. It has a longer duration of action and greater hypolipidemic activity than niacin, and it is better tolerated than niacin with a low incidence of adverse effects.

Rapidly and completely absorbed from the gastrointestinal tract; Time to peak plasma concentrations: within 2 hours. Not bind to plasma proteins; the plasma half-life: about 2 hours. Not significantly metabolized and is excreted in the urine, largely unchanged. Acipimox is efficiently removed with hemodialysis.

Patients with peptic ulcer disease. It should be used with caution in renal impairment

Do not take acipimox during pregnancy

women who are taking acipimox should not breast-feed

may cause peripheral vasodilatation resulting in flushing, itching, and a sensation of heat. Rash and erythema may occur. Gastrointestinal disturbances including heartburn, epigastric pain, nausea, and diarrhoea have been reported, as well as headache, malaise, myalgia, myositis, arthralgia, and dry eye.

Adults: PO 250 mg BID or TID, taken with meals. MAX dose: 1200 mg/day.

Dosage in renal failure: ClCr: 80-40 mL/min: 250 mg QD; 40-20 mL/min: 250 mg Q2D.（根據藥品仿單）