#特殊劑型：不建議磨粉、管灌藥品

Overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

Oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. It increases bladder (vesical) capacity and decreases urgency and the frequency of both incontinent episodes and voluntary urination.

Oxbu is an extended-release oral tablet formulation. Its duration is 24hrs; Protein binding: >99%, mainly to alpha-1 acid glycoprotein; extensively metabolized in liver and intestinal wall via CYP3A4, forms active and inactive metabolites.

Urinary retention, gastric retention and other severe decreased gastrointestinal motility conditions, uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions.

B

Excretion in breast milk unknown/use caution

Dry mouth (most common), constipation, diarrhea, dyspepsia, headache, dry eye

Extended release tab: Initial: 5-10 mg once daily, adjust dose in 5 mg increments at weekly intervals; maximum: 30 mg daily. Extended release tablets must be swallowed whole with liquid; do not crush, divide, or chew; take at approximately the same time each day.