【藥品性質提示】 1. 根據 2019 AGS Beers Criteria，本藥品為【潛在不適當用藥 (PIM)】，非下述情況之老年病患，不建議使用超過八周：潰瘍高風險族群(如長期使用口服類固醇、NSAID)、糜爛性食道炎(EE)、胃酸分泌過多、無法使用H2 antagonist者。 2. 該藥品為腸溶劑型，不建議磨粉

PPI Duodenal ulcer disease, erosive esophagitis, gastric ulcer; gastroesophageal reflux disease, Helicobacter pylori gastrointestinal tract infection.

Rabeprazole is a gastric proton-pump (H+/K+ATPase) inhibitor, with pharmacologic activity and a chemical structure similar to lansoprazole and omeprazole. The activity of rabeprazole on acid secretion is dose dependent. However, rabeprazole is more potent and has a quicker onset than omeprazole.

Absorption:
1. Onset of action: 1 hour
2. Duration: 24 hours
3. Oral bioavailability: 52%
Distribution:
Protein binding: 95-98%
Metabolism:
1. Extensively metabolized in liver via CYP3A and 2C19 to inactive metabolites
2. Elimination half-life: 1-2 hrs

Hypersensitivity to rabeprazole or benzimidazoles.

B

Infant risk cannot be ruled out.

Headache, diarrhea, nausea, abdominal pain, dizziness, edema, rash

20 mg once daily ; may be taken with or without food; swallow whole; do not chew, or crush.