Treatment of peripheral vascular circulatory disorder.
藥理
Pentoxifylline, a synthetic xanthine derivative, is a hemorrheologic agent. The principal hemorrheologic effects of pentoxifylline in patients with peripheral vascular disease appear to be an increase in erythrocyte flexibility (deformability) and a secondary reduction in viscosity of whole blood; these effects are associated with a decrease in total systemic vascular resistance and subsequent improvement in blood flow, particularly in the microcirculation, and with increased tissue oxygenation.
藥動學
禁忌症
Recent myocardial infarction.
懷孕分類
C
哺乳分類
Pentoxifylline and its metabolites are distributed into milk. Because of the tumorigenic potential exhibited by pentoxifylline in rats, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
副作用
Nausea, dizziness, and flushing.
劑量和給藥方法
PO: 400 mg 3 times/day with meals, may reduce to 400 mg twice daily if GI or CNS side effects occur.