Acquired hypoprothrombinemia.
Drug action reversal, Anticoagulant.
Hemorrhage of newborn.
Hemorrhage of newborn; Prophylaxis.

Phytonadione is a vitamin which is necessary for the hepatic synthesis of prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X). It is a cofactor for a microsomal enzyme that triggers the post-translational carboxylation of peptide-bound glutamic acid residues into active coagulation factor .

Absorption:
IM: readily absorbed
Excretion:
Biliary, Renal

Hypersensitivity to any component of this medication

C (FDA)

Maternal medication usually compatible with breastfeeding.(AAP)
Infant risk is minimal.(MDX)

Serious:
Cardiovascular: Cardiac arrest, Shock
Endocrine metabolic: Metabolic acidosis
Neurologic: Central nervous system depression
Respiratory: Gasping for breath, Respiratory arrest.

Acquired hypoprothrombinemia:
2.5 to 25 mg ORALLY (rarely up to 50 mg)
2.5 to 25 mg IV or SUBQ (rarely up to 50 mg); if prothrombin time is not satisfactory within 6 to 8 hours, repeat dose
Drug action reversal, Anticoagulant:
2.5 to 25 mg orally (rarely up to 50 mg); if prothrombin time is not satisfactory within 12 to 48 hours, repeat dose
2.5 to 25 mg IV or subQ (rarely up to 50 mg); if prothrombin time is not satisfactory within 6 to 8 hours, repeat dose
5 to 10 mg slow IV injection, in addition to 4-factor prothrombin complex concentrate, for major bleeding .

Hemorrhage of newborn:
1 mg SUBQ or IM
Hemorrhage of newborn; Prophylaxis:
(term infants), 1 mg IM soon after birth
(preterm infants) body weight at least 1 kg at birth, 0.5 mg IM soon after birth
(preterm infants) body weight less than 1 kg at birth, 0.3 mg/kg IM soon after birth
(when IM unavailable) 1 to 2 mg ORALLY at birth, 1 to 2 weeks of age, and 4 weeks of age OR 2 mg at birth followed by 1 mg ORALLY once weekly for 3 months OR 25 mcg ORALLY daily for 3 months