#建議持續輸注 (IV pump) 之高警訊藥品

Septic shock and other vasodilatory shock states: To increase BP in adults with vasodilatory shock (eg, postcardiotomy or sepsis) who remain hypotensive despite fluid resuscitation and catecholamines

Antidiuretic Hormone Analog
Antidiuretic (central diabetes insipidus) effect; at greater than physiologic doses, vasopressin has a pressor effect due to vasoconstriction and causes contraction of the smooth muscle of the gastrointestinal tract.

Absorption:
1. None from GI tract, destroyed by trypsin in GI tract, must be administered parenterally
2. Duration: (Antidiuretic) 2 to 8 hours; (Vasopressor effect) Within 20 minutes after IV infusion terminated
Distribution:
1. Vd: 140 mL/kg
2. Protein binding: None
Metabolism:
Hepatic, renal (inactive metabolites)
Excretion:
1. SUBQ: Urine (5% as unchanged drug) after 4 hours
2. IV: Urine (~6% as unchanged drug)
3. Half-life elimination: 10 to 20 minutes

1. Anaphylaxis or hypersensitivity to the components
2. Hypersensitivity to chlorobutanol

C

Enters breast milk/use caution

1. Cardiovascular: Atrial fibrillation, bradycardia, ischemic heart disease, limb ischemia (distal), low cardiac output, right heart failure, shock (hemorrhagic)
2. Dermatologic: Skin lesion (ischemic)
3. Endocrine & metabolic: Hyponatremia
4. Gastrointestinal: Mesenteric ischemia
5. Hematologic & oncologic: Decreased platelet count, hemorrhage
6. Hepatic: Increased serum bilirubin
7. Renal: Renal insufficiency
8. Postmarketing: Diabetes insipidus (reversible)

Shock, sepsis:
1. Initial: 0.03 units/min added to norepinephrine as a fixed dose (not titrated); usual dosage range 0.01 to 0.04 units/minute
2. Doses >0.04 units/minute should be reserved for salvage therapy due to potential risk of ischemic complications (eg, skin, cardiac, splanchnic)
Shock, post-cardiotomy:
1. Initial: 0.03 units/minute; If the target blood pressure response is not achieved, titrate up by 0.005 units/minute at 10- to 15-minute intervals (maximum dose: 0.1 units/minute)
2. After target blood pressure has been maintained for 8 hours without the use of catecholamines, taper by 0.005 units/minute every hour as tolerated to maintain target blood pressure

There are no dosage adjustments provided in the manufacturer's labeling.

There are no dosage adjustments provided in the manufacturer's labeling.