Inhibition of platelet aggregation (phosphodiesterase III inhibitor)
藥動學
Onset of action: 2-4 weeks, may require up to 12 weeks
Bioavailability: 87-100%; high fat meal increases absorption
Protein binding: 95-98%
Metabolism: metabolized in liver primarily via CYP3A4 and lesser CYP2C19
Elimination half- life: 11-13 hr
禁忌症
hypersensitivity to cilostazol, CHF of any severity
Administration:
Give 30 min before or at least 2 hours after food Dosage:
100 mg BID, dosage should be reduced to 50 mg twice daily during concurrent therapy with inhibitors of CYP3A4 or CYP2C19 (e.g., diltiazem, ketoconazole, itraconazole, erythromycin, omeprazole)