藥碼
PRO17
藥名
Alprostadil (PGE1) 20 mcg/Vial
英文商品名
Promostan 針 20 mcg/Vial
中文商品名
保脈暢注射劑
螢幕名
Promostan 針 20 mcg/Vial
劑型
Inj
規格
Inj 20mcg/Vial
成分
藥理分類
Misc. Vasodilating Drugs
健保碼
BC18720238
ATC碼
藥品圖片
外觀圖片
適應症
周邊動脈阻塞疾病症狀改善 (動脈內或大靜脈內點滴注射);血行再建術後之血流維持 (靜脈內投與)
藥理
Prostaglandin; Vasodilator
Alprostadil, the naturally occurring prostaglandin E1, is a vasodilating agent and a platelet-aggregation inhibitor.
藥動學
1. Onset of action: (Erectile dysfunction) 5 to 20 minutes
2. Protein binding: 81% to albumin
3. Metabolism: ~70% to 80% by oxidation during a single pass through the lungs; metabolite (13,14 dihydro-PGE1) is active and has been identified in neonates
4. Half-life elimination: 30 seconds to 10 minutes
5. Excretion: Primarily urine (90% as metabolites) within 24 hours; feces
禁忌症
1. Neonates with respiratory distress syndrome
2. Hypersensitivity
3. Sickle cell anemia, multiple myeloma; leukemia
4. Intracavenous injection is contraindicated in men who might be predisposed to priapism and whom sexual activity is inadvisable or contraindicated
懷孕分類
B
哺乳分類
副作用
Flushing, nausea, abdominal cramps, tachycardia/bradycardia, hypotension, general malaise, edema, apnea, fever, seizure
劑量和給藥方法
Intraarterial
1. Administration: 1 vial (Alprostadil 20mcg) diliuted with 5mL normal saline; admister by IA infusion pump
2. Dosage: 10-15 mcg (0.1-0.15 ng/kg/min) per day; may titrate to between 0.05-0.2 ng/kg/min
Intravenous
1. Administration: 2-3 vial (Alprostadil 40-60mcg) diliuted with 500mL normal saline; administer over 2hrs
2. Dosage: 5-10 ng/kg/min, once to twice daily; do not exceed 1.2 mcg/kg within 2 hours
Raynaud's phenomenon: (Off-label)
6-10 ng/kg/min IV for 12-72 hours
小兒調整劑量
腎功能調整劑量
There are no dosage adjustments provided in the manufacturer's labeling.
肝功能調整劑量
There are no dosage adjustments provided in the manufacturer's labeling.
安定性
NS or D5W may be used to prepare Prostaglandin E1 dilution of 2-20mg/L, and should be discarded after 24 hours.
藥袋資訊
臨床用途
末梢血管循環障礙
主要副作用
注射部位紅腫、疼痛、靜脈炎、無力感、頭痛、發熱等
泡製方法
儲存方式
請置於 15-30℃ 乾燥處儲存
注意事項
其他說明
藥局 a1 | 藥庫 注E11
藥品外觀
顏色
形狀
剝痕
標記1
標記2
其他
健保藥價
569
自費價
756.77
仿單
資料庫
健保給付規定