周邊動脈阻塞疾病症狀改善 (動脈內或大靜脈內點滴注射)；血行再建術後之血流維持 (靜脈內投與)

Prostaglandin; Vasodilator
Alprostadil, the naturally occurring prostaglandin E1, is a vasodilating agent and a platelet-aggregation inhibitor.

1. Onset of action: (Erectile dysfunction) 5 to 20 minutes
2. Protein binding: 81% to albumin
3. Metabolism: ~70% to 80% by oxidation during a single pass through the lungs; metabolite (13,14 dihydro-PGE1) is active and has been identified in neonates
4. Half-life elimination: 30 seconds to 10 minutes
5. Excretion: Primarily urine (90% as metabolites) within 24 hours; feces

1. Neonates with respiratory distress syndrome
2. Hypersensitivity
3. Sickle cell anemia, multiple myeloma; leukemia
4. Intracavenous injection is contraindicated in men who might be predisposed to priapism and whom sexual activity is inadvisable or contraindicated

B

Flushing, nausea, abdominal cramps, tachycardia/bradycardia, hypotension, general malaise, edema, apnea, fever, seizure

Intraarterial
1. Administration: 1 vial (Alprostadil 20mcg) diliuted with 5mL normal saline; admister by IA infusion pump
2. Dosage: 10-15 mcg (0.1-0.15 ng/kg/min) per day; may titrate to between 0.05-0.2 ng/kg/min
Intravenous
1. Administration: 2-3 vial (Alprostadil 40-60mcg) diliuted with 500mL normal saline; administer over 2hrs
2. Dosage: 5-10 ng/kg/min, once to twice daily; do not exceed 1.2 mcg/kg within 2 hours
Raynaud's phenomenon: (Off-label)
6-10 ng/kg/min IV for 12-72 hours

There are no dosage adjustments provided in the manufacturer's labeling.

There are no dosage adjustments provided in the manufacturer's labeling.

NS or D5W may be used to prepare Prostaglandin E1 dilution of 2-20mg/L, and should be discarded after 24 hours.