"Treatment and outcome of nausea and vomiting of pregnancy
Isoniazid (INH) poisoning
Treatment of neonatal seizures
"

Vitamin

"Absorption
Bioavailability: readily absorbed
Distribution
Protein binding: extensive, serum albumin
Metabolism
Liver: significant
Excretion
Renal: 35% to 63%
Bile: 2%
Elimination Half Life
15 to 20 days
"

A history of sensitivity to pyridoxine or to any of the ingredients in Pyridoxine Hydrochloride Injection, USP is a contraindication.

Fetal risk is minimal.

Infant risk is minimal.

Paresthesia, somnolence, and low serum folic acid levels have been reported.

"Pyridoxine Hydrochloride Injection may be administered intramuscularly or intravenously. In cases of dietary deficiency, the dosage is 10 to 20 mg daily for 3 weeks. Follow-up treatment is recommended daily for several weeks with an oral therapeutic multivitamin preparation containing 2 to 5 mg pyridoxine. Poor dietary habits should be corrected, and an adequate, well balanced diet should be prescribed.
The vitamin B6 dependency syndrome may require a therapeutic dosage of as much as 600 mg a day and a daily intake of 30 mg for life.
In deficiencies due to INH, the dosage is 100 mg daily for 3 weeks followed by a 30 mg maintenance dose daily.
In poisoning caused by ingestion of more than 10 g of INH, an equal amount of pyridoxine should be given — 4 g intravenously followed by 1 g intramuscularly every 30 minutes.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
"

not found

No dosage adjustment necessary.

No dosage adjustment necessary.