抗病毒藥品 Treatment of acute, uncomplicated influenza in patients ≥6 months of age who have been symptomatic ≤2 days

Antiviral Agent; Neuraminidase Inhibitor:
Peramivir is an antiviral agent (neuraminidase inhibitor), which inhibits neuraminidase activity by binding to the active site of several influenza virus A and B strains.

Distribution:
Vd: 12.56 L; Protein binding: <30%
Metabolism:
1. Not significantly metabolized
2. Half-life elimination: ~20 hours
Excretion:
Urine (~90% as unchanged drug)

Severe allergic reaction to any other neuraminidase inhibitor (zanamivir or oseltamivir) or any ingredient in the product.

C: No data available for use during pregnancy.

Avoid, No data available

Diarrhea, Nausea, Vomiting, Neutropenia, ALT/SGPT level raised, Prolonged QT interval

Influenza, acute, uncomplicated:
300 mg as a single dose; initiate within 2 days of onset of symptoms of influenza

1. CrCl 31 to 49 mL/min: 150 mg daily
2. CrCl 10 to 30 mL/min: 100 mg daily
3. CrCl <10 mL/min (not on dialysis or renal replacement therapy): 100 mg on day 1, then 15 mg daily thereafter
4. ESRD on Intermittent hemodialysis: 100 mg on day 1, then 100 mg given 2 hr after each HD session on dialysis days only