It is used to reduce serum phosphorus in patients with chronic kidney disease (CKD) who are undergoing dialysis.1

Sevelamer hydrochloride (a polymeric compound) binds phosphate within the intestinal lumen, limiting absorption and decreasing serum phosphate concentration. It is hydrophilic, but insoluable in water.

Sevelamer is not systemically absorbed; Excretion: feces

patients with hypophosphatemia or bowel obstruction.

C

Avoided

Nausea, vomiting, constipation (2%), diarrhea ( 4%), flatulence (4%), dyspepsia( 5%), pruritus, limb pain, arthralgia.

800 to 1600 mg orally administered with each meal. Swallow whole; do not crush, chew, or break. Dosage should be adjusted based on the serum phosphorous level with a goal of lowering serum phosphorous to 5.5 mg/ dL. The dose may be increased or decreased by one tablet per meal.