糖尿病 (其他)
Repaglinide is an oral agent of the meglitinide class used for treating noninsulin dependent diabetes mellitus.
藥理
Repaglinide has significantly reduced postprandial blood glucose in type 2 diabetes; minimal effects on fasting blood glucose were observed.
藥動學
Rapidly absorbed following oral administration. Extensively metabolized in the liver and excreted predominantly via the feces; Elimination half-life: less than one hour.
禁忌症
Hypersensitivity to repaglinide; insulin dependent diabetes mellitus; ketoacidosis
懷孕分類
C
哺乳分類
Because of the potential for repaglinide to cause hypoglycemia and resultant skeletal changes in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
副作用
Hypoglycemia is the major adverse effect; nausea, diarrhea, constipation, vomiting, and dyspepsia were reported at a similar incidence to placebo and sulfonylureas.
劑量和給藥方法
0.5-4 mg PO AC; the maximum total daily dose should not exceed 16 mg