Distribution :
VD: 0.6 L/kg
Metabolism:
Piracetam is not metabolized in the body
Elimination Half-life:
5 to 6 hours.
禁忌症
Previous hypersensitivity to piracetam
Huntington's chorea.
懷孕分類
Fetal risk cannot be ruled out.(MDX)
哺乳分類
Infant risk cannot be ruled out.(MDX)
副作用
NAUSEA, GASTRIC DISCOMFORT, ABDOMINAL PAIN, and FLATULENCE have been described occasionally during piracetam therapy.
High doses of piracetam have been associated with HYPERSTIMULATION, SLEEP DISTURBANCES, and DIZZINESS in some patients .
劑量和給藥方法
Cognitive disorders: 1.2 to 4.8 g daily in 2 to 4 divided doses.
Cortical myoclonus, adjunctive: Initial: 7.2 g daily administered in 2 to 3 divided doses; may increase total daily dose by 4.8 g every 3 to 4 days if needed (maximum daily dose: 24 g).
Vertigo: 2.4 to 4.8 g daily in 2 to 3 divided doses.(UTD)
小兒調整劑量
腎功能調整劑量
pharmacokinetic studies in these patients are lacking.