Decreases the sensitivity of cough receptors and interrupts cough impulse transmission by depressing the medullary cough center through sigma receptor stimulation; structurally related to codeine
藥動學
See individual agents.
禁忌症
Concurrent administration with or within 2 weeks of discontinuing an MAO inhibitor.
懷孕分類
Avoid use. When an antitussive is needed during pregnancy, dextromethorphan at standard OTC doses is generally considered acceptable. Some sources recommend use be reserved for significant maternal need.
哺乳分類
Avoid use
副作用
Central nervous system: Confusion, excitement, irritability, nervousness, serotonin syndrome