藥碼
SAN06
藥名
Octreotide 0.1 mg/mL, 1 mL/amp
英文商品名
低 Sandostatin 針 0.1 mg/Amp
中文商品名
善得定注射劑
螢幕名
低 Sandostatin 針 0.1 mg/Amp
劑型
Inj
規格
Inj 0.1mg/ml/Amp
成分
藥理分類
Somatotropin Antagonists
健保碼
BC17873209
ATC碼
適應症
Control of symptoms (diarrhea and flushing) in patients with metastatic carcinoid tumors; treatment of watery diarrhea associated with vasoactive intestinal peptide-secreting tumors (VIPomas); treatme tof acromegaly.
藥理
Octreotide is a synthetic octapeptide derivative of naturally occurring somatostatin with similar pharmacological effects, but with a considerably prolonged duration of action. It inhibits pathologically increased secretion of growth hormone (GH) and of peptides and serotonin produced within the gastro-entero-pancreatic (GEP) endocrine system.
藥動學
Bioavailability: (subcutaneous, long-acting), 60% to 63% compared to immediate-release form; Protein binding: about 65%; Renal excretion: about 32% unchanged; Elimination Half Life: 1.7 hr, prolonged in renal impairment(2.4-3.1 hr), liver cirrhosis(3.7 hr) and the elderly( increased by 46%).
禁忌症
Known hypersensitivity to octreotide or any of its components
懷孕分類
B
哺乳分類
Excretion in breast milk unknown/use caution
副作用
injection site localized pain; gastrointestinal disorders such as diarrhea, constipation, abdominal pain, nausea; headache, dizziness, hepatobiliary disorders, hyperglycemia, anorexia.
劑量和給藥方法
50-100 mcg SC BID or TID. Repeated injections at the same site in short periods of time should be avoided. Continuous I.V. infusion rates (unlabeled administration rate) have ranged from 25-50 mcg/hour for the treatment of esophageal variceal bleeding (unlabeled use); continuous I.V. infusion rates of 100-125 mcg/hour have been used for the treatment of sulfonylurea-induced hypoglycemia.
小兒調整劑量
腎功能調整劑量
肝功能調整劑量
安定性
should be stored in the refrigerator at 2 to 8℃
注射給藥指引
給藥途徑
IV (靜脈注射)、IVD (靜脈滴注)、SC(皮下注射)(仿單)
靜脈輸注液
再生溶液：不需再生。稀釋溶液：NS、D5W。
每瓶稀釋液體積
IVD(靜脈滴注)：加入NS或D5W至50-200mL
注射濃度
給藥速率
IV (靜脈注射)：超過3分鐘，IVD (靜脈滴注)：超過15-30分鐘
安定性
should be stored in the refrigerator at 2 to 8℃
注意事項
相容：aminophylline、
amiodarone、
bumetanide、
calcium chloride、
calcium gluconate、
cisatracurium、
dexmedetomidine、
diltiazem、
dobutamine、
dopamine、
epinephrine、
esmolol、
fentanyl、
furosemide、
heparin、
isoproterenol、
insulin、
labetalol、
lansoprazole、
lidocaine、
lorazepam、
magnesium sulfate、
mannitol、
midazolam、
milrinone、
nicardipine、
nitroglycerin、
norepinephrine、
potassium chloride、
sodium bicarbonate、
vasopressin
完整資訊請見重症常用藥品靜脈相容性表
完整資訊請見重症常用藥品靜脈相容性表
藥袋資訊
臨床用途
治療肢端肥大症，胃腸胰臟內分泌腫瘤相關症狀、胃食道靜脈曲張引起的出血、急性胰臟炎。
主要副作用
注射部位疼痛或刺痛感、食慾不振、腹脹、腹瀉或軟便等
泡製方法
儲存方式
請置於 2-8℃ 冷藏儲存
注意事項
其他說明
急首 X6-2 | 藥庫 冰Z32 | <一盒5支>
藥品外觀
顏色
形狀
剝痕
標記1
標記2
其他
健保藥價
376
自費價
500.08
仿單
資料庫
健保給付規定