#高警訊藥品
鈉、氯補充劑 For severe hyponatremia and hypochloremia
藥理
Electrolyte Supplement
Principal extracellular cation; functions in fluid and electrolyte balance, osmotic pressure control, and water distribution
藥動學
禁忌症
1. Congestive heart failure
2. Severe renal impairment
3. Edema with sodium retention
懷孕分類
C
哺乳分類
副作用
Phlebitis, Injection site extravasation, Injection site reaction, Hypervolemia
劑量和給藥方法
Administration:
1. Administration through a central line is recommended due to high osmolarity and tonicity.
2. To calculate sodium deficit, use the following formula: (140 mEq/L - patient's serum Na) x (total body water in liters) = mEq Na. Dosage:
1. Dose should be guided by serum sodium levels, clinical condition, patient age and weight.
2. Goal of initial therapy is to achieve a 24 hour increase in serum sodium concentration by 4-6 mEq/L (maximum serum sodium increase: 8 mEq/L in any 24-hour period).
3. Using hypertonic (3% or 5%) solutions for replacement, administer half of dose over 8 hours, not to exceed a maximum of 100 milliliter/hour.
4. Continue treatment until serum sodium is 130 mEq/L or neurologic symptoms improve. Remainder of deficit can be replaced over several days.