Febrile seizure; Seizures; Sedation, anxiolysis, and amnesia prior to procedure

Febrile seizure; Seizures; Sedation, anxiolysis, and amnesia prior to procedure

Onset of action: 2-10 minutes; Bioavailability: 90%; Absorption: Well absorbed; Distribution: 1 L/kg; Metabolism: Hepatic; diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam. N-desmethyldiazepam and temazepam are both further metabolized to oxazepam. Temazepam and oxazepam are largely eliminated by glucuronidation.; Half-life elimination: Parent: 45-46 hours; Desmethyldiazepam: 71-99 hours; Time to peak: 1.5hr; Excretion: Urine

Hypersensitivity to diazepam, myasthenia gravis, sleep apnea syndrome, severe respiratory impairment, severe hepatic impairment

D[FDA]

Diazepam is excreted in the breast milk and therefore its use during lactation should be avoided.

Rash, diarrhea, muscle weakness, ataxia, incoordination, euphoria, fatigue, respiratory depression

0.25-1mg/kg

Seizures, acute: Rectal gel formulation:Infants and Children 6 months to 2 years: Rectal: Dose not establishedChildren 2 to 5 years: Rectal: 0.5 mg/kgChildren 6 to 11 years: Rectal: 0.3 mg/kgChildren ?12 years and Adolescents: Rectal: 0.2 mg/kgNote: Round dose to the nearest 2.5 mg increment, not exceeding a 20 mg/dose; dose may be repeated in 4 to 12 hours if needed; do not use more than 5 times per month or more than once every 5 days

There are no dosage adjustments provided in the manufacturer’s labeling; use with caution.

There are no dosage adjustments provided in the manufacturer’s labeling; use with caution.

Store at 25°C