【藥品訊息】 沙法克寧懸液劑 仿單

Sulfonamides類抗生素 Urinary tract infections caused by susceptible strains of E. coli, Proteus, Klebsiella, Enterobacter, H. influenzae, S. pneumoniae, Shigella spp.

Trimethoprim: Antibiotic, Miscellaneous
Trimethoprim inhibits dihydrofolic acid reduction to tetrahydrofolate resulting in sequential inhibition of enzymes of the folic acid pathway
Sulfamethoxazole: Antibiotic, Sulfonamide Derivative
Sulfamethoxazole interferes with bacterial folic acid synthesis and growth via inhibition of dihydrofolic acid formation from para-aminobenzoic acid

Absorption: Rapid; almost completely
Distribution:
1. Both SMX and TMP distribute to middle ear fluid, sputum, vaginal fluid; TMP also distributes into bronchial secretions
2. Protein binding: (SMX) ~70%; (TMP) ~44%
Metabolism: Hepatic, both to multiple metabolites; SMX to hydroxy (via CYP2C9) and acetyl derivatives, and also conjugated with glucuronide; TMP to oxide and hydroxy derivatives; the free forms of both SMX and TMP are therapeutically active
Time to peak: 1 to 4 hours
Excretion: Both are excreted in urine as metabolites and unchanged drug

1. Pregnancy, infants younger than 2 months, lactation
2. Hypersensitivity to sulfonamides or trimethoprim, patients with impaired renal or hepatic function

C

Probably safe, except in premature infant or infant with G6PD deficiency.

Agranulocytosis, aplastic and megaloblastic anemia, nausea, erythema multiforme, headache, depression

In urinary tract infection, MAX trimethoprin 640mg/Sulfamethoxazole 3.2g

8 mg/kg trimethoprim and 40 mg/kg sulfamethoxazole daily, give in 2 divided dose Q12H