Beta2 Agonist; Beta2-Adrenergic Agonist, Long-Acting; Corticosteroid, Inhalant (Oral)
1.The combination is indicated for the maintenance treatment of asthma in adult and pediatric patients 6 years and older.
2.Budesonide; formoterol is also indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults and to reduce the risk of exacerbations of COPD.

1.Formoterol: Relaxes bronchial smooth muscle by selective action on beta2 receptors with little effect on heart rate; formoterol has a long-acting effect.
2.Budesonide: A corticosteroid which controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes/fibroblasts, and reverses capillary permeability and lysosomal stabilization at the cellular level to prevent or control inflammation.

1.Budesonide:
Metabolism: Hepatic via CYP3A4
Half-life elimination: Adults: 2 to 3.6 hours
Excretion: Urine (60%) and feces as metabolites
2.Formoterol:
Metabolism: extensively metabolized in the liver.
Excretion: About 62% of a dose is eliminated in the urine and 24% in the feces.

Hypersensitivity to budesonide, formoterol, or any component of the formulation; primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required

Adverse events were observed in animal reproduction studies using this combination.

According to the manufacturer, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother.

back pain, headache, influenza, nasal congestion, naso-pharyngitis , vomiting, pharyngo-laryngeal pain, sinusitis, stomach discomfort , and upper respiratory tract infection .

Asthma (controller/maintenance):
2 inhalations twice daily
Chronic obstructive pulmonary disease:
2 inhalations twice daily; Maximum 2 inhalations twice daily

For asthma maintenance: 2 inhalations twice daily

There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).

There are no dosage adjustments provided in the manufacturer's labeling (has not been studied); use with caution and monitor closely; may lead to accumulation of budesonide and formoterol.