community-acquired pneumonia

Nemonoxacin is a non-fluorinated quinolone antibiotic. It has the same mechanism of action as fluouroquinolones; it inhibits DNA gyrase, preventing DNA synthesis, gene duplication, and cell division.

Distribution:
1.Plasma protein binding: 44 to 48%.
2.Volume of distribution:approximately 200L, indicating widespread distribution throughout various tissues in the body.
Excretion: primarily eliminated through renal .

1. Hypersensitivity to Nemonoxacin or quinolone.
2. Pregnancy/ breastfeeding.

This medication's safety has not been established in pregnant women.It is contraindicated in pregnant women or women who may become pregnant.

Avilable evidence and/or expert consensus is inconclusive or is inadequate for determining infant risk when used during breastfeeding. Use during breastfeeding is not recommended.

Abdominal Pain, diarrhea, nausea, dizziness, headache, itching, rash

Dosage: 250 ml (0.5 grams of nemonoxacin) once daily. ( Slow intravenous infusion over a period of not less than 90 minutes)

1. CrCl 60-90 mL/min: No adjustment required.
2. CrCl <60 mL/min, ESRD: Use is not recommended.

There are no adequate and well-controlled studies of Nemonoxacin in patient with hepatic failure.