【缺藥訊息】 公告日期：2023/12/21。 缺藥品項：Tazocin 針 2.25 gm。 缺藥原因：因製造問題缺藥。 替代藥品：國內有同成份規格替代品。 配套措施：採購替代品，庫存量用罄關檔停用，替代品 Pipe Tazo 針 2.25 gm 已到貨。

下呼吸道感染、尿路感染（複雜及非複雜性）、腹腔內感染、皮膚及皮膚結構感染，細菌性敗敗症、嗜中性性性球減少病病的細菌性感染，多菌種感

Antibiotic, Penicillin

Distribution: Piperacillin: 0.243 L/kg.
Protein binding: Piperacillin: ~26% to 33%; Tazobactam: 31% to 32%.
Metabolism: Piperacillin: 6% to 9% to desethyl metabolite (weak activity); Tazobactam: ~22% to inactive metabolite.
Bioavailability: IM: Piperacillin: 71%; Tazobactam: 84%.
Half-life elimination: Piperacillin: 0.7 to 1.2 hours; Tazobactam: 0.7 to 0.9 hour.
Excretion: Urine, feces.

Hypersensitivity to penicillins, cephalosporins, beta-lactamase inhibitors, or any component of the formulation.

B

Piperacillin is present in breast milk.

>10%: diarrhea (11%).
1% to 10%: flushing (≤1%), hypotension (≤1%), phlebitis (1%), thrombophlebitis (≤1%), pruritus (3%), skin rash (4%), hypoglycemia (≤1%), abdominal pain (1%), clostridioides difficile colitis (≤1%), constipation (8%), dyspepsia (3%), nausea (7%), vomiting (3%), purpuric disease (≤1%), anaphylaxis (≤1%), candidiasis (2%), injection-site reaction (≤1%), headache (8%), insomnia (7%), rigors (≤1%), arthralgia (≤1%),epistaxis (≤1%), fever (2%).

1. The usual adult total daily dose of Tazocin: 12.0 g/1.5 g (6 vial) to 16.0 g/2.0 g (8 vial) ; 4.5 g every six to 8 hours.
2. Hospital-acquired or ventilator-associated pneumonia: Initial dose: 4.5 g every 6 hours, with a total daily dose of 18 g (16.0 g Piperacillin/2.0 g Tazobactam).

Appendicitis and peritonitis:
≥9 months , ≤40kg: 100 mg Piperacillin/ 12.5 mg Tazobactam/kg every 8 hours.
2 months to 9 months: 80 mg Piperacillin/ 10 mg Tazobactam/kg every 8 hours.

If the usual recommended dose is 4.5 g every 6 hours
CrCl (100 to <130 mL/minute): Extended infusion preferred.
CrCl (40 to <100 mL/minute): 4.5 g every 6 hours.
CrCl (20 to <40 mL/minute): 4.5 g every 8 hours or 3.375 g every 6 hours.
CrCl (<20 mL/minute): 4.5 g every 12 hours or 2.25 g every 6 hours.

No dosage adjustment necessary.