Acne vulgaris, bacterial infections, anthrax, chlamydial infection, cholera, syphilis.

Tetracyclines are broad-spectrum bacteriostatic compounds that inhibit protein synthesis at the 30S ribosomal subunit. Activity includes G (+), G (-), aerobic, and anaerobic bacteria, as well as spirochetes, mycoplasmas, rickettsiae, chlamydiae, and some protozoa.

Oral absorption 75%, protein binding: ~65%, 60 % is unchanged renal excretion, t1/2: 8~11hr in normal renal function, 57~108 hrs in ESRD

hypersensitivity to any tetracycline products, last half of pregnancy, infancy, and childhood up to 8 years of age

D

Enters breast milk/not recommended

Photosensitivity, rash, nausea, diarrhea, discoloration of teeth and enamel hypoplasia especially during growth.

Adults: 250-500 mg orally every 6 hours.
Children >8 years: 25-50 mg/kg/day in divided doses every 6 hours.
Administration: Avoid concomitant administration of aluminum, calcium, and magnesium, which can impair absorption of tetracycline. Take 1 hr before or 2 hr after meals.