維他命B1缺乏症。

Vitamin, Water Soluble

Distribution: Highest concentrations found in brain, heart, kidney, liver.
Metabolism: In the liver.
Excretion: Urine.

Hypersensitivity to thiamine or any component of the formulation.

D; Water soluble vitamins cross the placenta. Thiamine requirements are increased in during pregnancy.

Thiamine is present in breast milk.

Frequency not defined: flushing sensation, restlessness, diaphoresis, pruritus, skin sclerosis, urticarial, nausea, hemorrhage, anaphylaxis, angioedema, hypersensitivity reaction, tenderness at injection site, weakness, cyanosis, pharyngeal edema, pulmonary edema.

1. Beriberi treatment: Initial: IV: 100 to 200 mg 3 times daily for 2 to 3 days, followed by maintenance therapy.
2. Ethylene glycol poisoning (adjunctive agent) (off-label use): IV: 100 mg as a one-time dose.
3. Thiamine supplementation, including prevention of Wernicke encephalopathy:
Wernicke encephalopathy, prevention, including those with alcohol withdrawal syndrome (off label): IV: 100 to 200 mg once daily for 3 to 5 days.
Parenteral nutrition supplementation: Continuous IV infusion: 6 mg/day.
4. Wernicke encephalopathy, treatment: IV: 200 to 500 mg 3 times daily for 2 to 7 days, followed by 250 mg once daily for an additional 3 to 5 days, followed by maintenance therapy.

1. Parenteral nutrition, maintenance requirement:
Infants: IV: 0.35 to 0.5 mg/kg/day; maximum daily dose: 1.2 mg/day.
Children and Adolescents: IV: 1.2 mg/day.
2. Thiamine deficiency; treatment:
Infants: Initial dose: IV: 100 mg once daily.
Children and Adolescents: Initial dose: IV: 100 mg once daily for up to 7 days.

No dosage adjustment likely to be necessary.