痤瘡 For the topical treatment of acne vulgaris

Adapalene is a retinoid-like compound, and a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Onset: 8-12 weeks; absorption through human skin is low; excretion primarily via the biliary route.

Hypersensitivity to adapalene or any of its components

C

Avoided

Dry skin, erythema, pruritus, scaly skin, skin irritation, and burning sensation

Apply once daily to the affected areas after washing at bedtime. Avoid contact with the eyes, lips, angles of nose, and mucous membranes. Avoid excessive exposure to sunlight, including sunlamps. Do not apply to cuts, abrasions, eczematous, or sunburned skin. Safety and efficacy have not been established in children less than 12 years of age.