Treatment of chronic open-angle glaucoma
#仿單變更2022

Timolol is a nonselective β-adrenergic blocking agent.

1. Onset of action: 30 minutes; Peak effect: 1 to 2 hours
2. Duration: 24 hours
3. Absorption: Timolol is measurable in the serum following ophthalmic use
4. Half-life elimination: 4 hours

Patient with bronchospasm, severe chronic obstructive pulmonary disease, or uncontrolled cardiac failure.

Timolol is absorbed systemically; additional adverse effects observed with systemic administration may occur.

Timolol is present in breast milk following ophthalmic administration. Due to the potential for adverse events, breastfeeding infants (especially those with cardiorespiratory problems) should be monitored.

1. Ophthalmic: Burning sensation of eyes, stinging of eyes, decreased corneal sensitivity, diplopia, tinnitus
2. Cardiovascular: Angina pectoris, bradycardia, cardiac arrhythmia, cardiac failure, cerebral ischemia, cerebrovascular accident, claudication, cold extremities, edema, heart block, hypertension, hypotension, palpitations, Raynaud's phenomenon
3. Respiratory: Bronchospasm, cough, dyspnea, respiratory failure
4. Dermatologic: Alopecia, exacerbation of psoriasis, psoriasiform eruption, skin rash, urticaria
5. Hypersensitivity: Angioedema, hypersensitivity reaction
6. Central nervous system: Amnesia, depression, disorientation, dizziness, drowsiness, exacerbation of myasthenia gravis, hallucination<20220127>, headache, insomnia, nervousness, nightmares, paresthesia
7. Gastrointestinal: Anorexia, diarrhea, dyspepsia, nausea, xerostomia
8. Genitourinary: Impotence, Peyronie's disease, retroperitoneal fibrosis
9. Neuromuscular & skeletal: Systemic lupus erythematosus
10. Endocrine & metabolic: Hypoglycemia (masked), decreased libido

1 drop QD