【藥品性質提示】 GFR <30 mL/min 以下之慢性腎臟疾病病人，建議勿處方本品 (NSAID)。

止痛消炎口服 Relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Aceclofenac, a phenylacetic acid derivative, is an NSAID related to diclofenac. Like other NSAIDS, aceclofenac is a prostaglandin synthetase (cyclooxygenase) inhibitor, which decreases prostaglandin and leukotriene production, therefore inhibiting the inflammatory process.

After absorption of aceclofenac, the drug is progressively hydrolyzed to diclofenac in the circulation. This reportedly results in higher and more constant diclofenac levels than those which result from administration of diclofenac itself, especially several hours after administration. Tmax: 1.25 to 3 hours; highly protein-bound (>99%) in plasma. The plasma-elimination half-life is about 4 hours.

Hypersensitivity to aceclofenac, aspirin, or other NSAIDs; Suspected peptic ulcer or gastrointestinal bleeding; moderate to severe renal impairment; during pregnancy, unless clearly necessary. 
Do not use this medication within 14 days after undergoing coronary artery bypass graft (CABG).<20240906>

unknown

Avoided.

Most adverse events are mild and reversible and primarily involve the GI system.

100mg twice daily after food. The initial oral dose of aceclofenac should be reduced to 100mg daily in patients with hepatic impairment. Aceclofenac should be avoided in patients with moderate to severe renal impairment.