藥碼
TYK01
藥名
Lapatinib 250 mg
英文商品名
Tykerb 錠劑 250 mg
中文商品名
泰嘉膜衣錠
螢幕名
Tykerb 錠劑 250 mg
劑型
Tab
規格
Film-coated tab 250 mg
成分
藥理分類
Anticancer- Protein kinase inhibitors
健保碼
BC24878100
ATC碼
藥品圖片
外觀圖片
適應症
In combination with capecitabine, for the treatment of patients with advanced or metastatic breast cancer whose tumours overexpress HER2+/neu (ErbB2+) and who have received prior therapy including anthracycline, taxane, and trastuzumab.
藥理
Lapatinib is a dual tyrosine kinase inhibitor against epidermal growth factor receptors (EGFR) HER1 and HER2. HER1 and HER2 are overexpressed in over 20% of breast tumors, and is a key component in regulating tumor cell growth, proliferation, metastasis, and transformation.
藥動學
Absorption: Incomplete and variable following oral administration; Effects of food: increased systemic exposure; Protein binding: >99% to albumin and alpha1-acid glycoprotein; Lapatinib undergoes extensive metabolism, primarily by CYP3A4 and CYP3A5, and to a lesser extent via CYP2C19 and 2C8 to oxidized metabolites; Elimination half-life: ~24 hours.
禁忌症
specific contraindications have not been determined
懷孕分類
D
哺乳分類
Excretion in breast milk unknown/not recommended
副作用
Rash (28%), hand-and-foot syndrome (53%; grade 3: 12%), fatigue, diarrhoea , dyspepsia, nausea, vomiting, anemia (56%), neutropenia (22%), thrombocytopenia(18%), AST increased (49%), total bilirubin increased (45%), ALT increased (37%)
劑量和給藥方法
1250 mg (i.e. five tablets) once daily continuously (days 1 through 21) in combination with capecitabine 2000 mg/m2/day ORALLY (divided into 2 doses every 12 hours) on days 1 through 14 in a repeating 21 day cycle until treatment progression of unacceptable toxicity. Do not divide the daily dose; doses should be taken once daily. Swallow tablet whole. Do not chew, break, or crush. Lapatinib should be taken at least one hour before, or at least one hour after food. Take capecitabine with food or within 30 min after food.
小兒調整劑量
腎功能調整劑量
肝功能調整劑量
安定性
藥袋資訊
臨床用途
標靶治療藥物
主要副作用
厭食、心臟功能下降、腹瀉、噁心、嘔吐、皮疹、疲勞
泡製方法
儲存方式
請置於 15-30℃ 乾燥處儲存
注意事項
其他說明
藥局 V3 | 藥庫 ★口A11
藥品外觀
顏色
06
形狀
03
剝痕
標記1
GS XJG
標記2
其他
健保藥價
21700
自費價
28861
仿單
資料庫
健保給付規定