Relief of bladder pain or discomfort associated with interstitial cystitis.

Pentosan polysulfte sodium is a low molecular weight heparin-like compound. It has anticoagulant (1/15 the activity of heparin) and fibrinolytic effects. Pentosan polysulfate sodium appears to adhere to the bladder wall mucosal membrane, where it may act as a buffer to protect the tissue from irritating substances.

Absorption: ~3%; Distribution: major distribute in uroepithelium of the genitourinary tract; Metabolism: 68% undergoes partial desulfation in the liver and spleen; Excretion: urine; Elimination half-life: 4.8 hrs.

Hypersensitivity to the drug, structurally related compounds (LMWHs or heparin), or any excipients.

B

Excretion in breast milk unknown/use caution

Alopecia, diarrhea, nausea, abdominal pain, headache, liver function abnormalities, dizziness.

100 mg orally three times a day. The capsules should be taken with water at least 1 hour before meals or 2 hrs after meals.