【藥品性質提示】 根據 2019 AGS Beers Criteria，本藥品為【潛在不適當用藥 (PIM)】，不建議用於老年人。

Anxiety; Muscle spasm; Seizures

Anticonvulsant, Benzodiazepine; Benzodiazepine

Absorption: Oral: Well absorbed (>90%); delayed and decreased when administered with a moderate fat meal Rectal: Well absorbed Distribution: Vd: IV: 1.2 L/kg Oral: 1.1 L/kg Rectal: 1 L/kg Protein binding: Oral: Neonates: 84% to 86% ; Adults: 98% Rectal: 95% to 98%

Hypersensitivity to diazepam or any component of the formulation; acute narrow-angle glaucoma; untreated open-angle glaucoma; infants <6 months of age (oral); myasthenia gravis, severe respiratory impairment, severe hepatic impairment, sleep apnea syndrome (oral tablet). Documentation of allergenic cross-reactivity for benzodiazepines is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.

D

Diazepam and its metabolites are present in breast milk.

Amnesia, ataxia, confusion, depression, drowsiness, dysarthria, fatigue, headache, slurred speech, vertigo,Skin rash,Blurred vision

Anxiety: 2 to 10 mg 2 to 4 times daily if needed Muscle spasm: 2 to 10 mg 3 or 4 times daily Seizures:Oral: 2 to 10 mg 2 to 4 times daily.

Oral: Children: 0.2 to 0.3 mg/kg (maximum dose: 10 mg) 45 to 60 minutes prior to procedure Adolescents: 10 mg

There are no dosage adjustments provided in the manufacturer's labeling; use with caution. Hemodialysis: Not dialyzable (0% to 5%); supplemental dose is not necessary.

There are no dosage adjustments provided in the manufacturer's labeling; use with caution. The oral tablets are contraindicated in severe hepatic impairment.

Store at 25 degrees C.