Relief of signs & symptoms of naturally or surgically induced estrogen deficiency.

The active form of estradiol valerate, synthetic 17β-estradiol is chemically and biologically identical to endogenous human estradiol. Medroxyprogesterone acetate is a derivative of the natural progesterone.

Estradiol valerate: Bioavailability: 53%, Protein binding: 61%, extensively metabolized-by P450 CYP3A4; enterohepatic recirculation via sulfate and glucuronide conjugation; Elimination half-life: 12 h to 14 h. Medroxyprogesterone acetate: well absorbed; Protein binding: 86% to 90% primarily to albumin; Metabolism: Extensively hepatic via hydroxylation and conjugation, forms metabolites; Elimination half-life: 12-17 hours.

Hypersensitivity to estradiol, or Medroxyprogesterone acetate; arterial thromboembolic disease; known or suspected breast or endometrial carcinoma ; deep vein thrombosis/pulmonary embolism; estrogen-dependent neoplasia; abnormal genital bleeding; liver dysfunction or disease.

X

Avoided

Nausea, anorexia, abdominal cramps; edema, weight & breast changes; headache, migraine, reactivation of endometriosis.

Orally, 1 tab daily in 21 day cycle. Take white pill for the first 11 days, and then take blue pill for 10 days. Total 28 day cycle (including 7 days drug free).