眼用抗感染 Bacterial conjunctivitis

Moxifloxacin is a DNA gyrase inhibitor, and also inhibits topoisomerase IV. DNA gyrase (topoisomerase II) is an essential bacterial enzyme that maintains the superhelical structure of DNA. DNA gyrase is required for DNA replication and transcription, DNA repair, recombination, and transposition; inhibition is bactericidal.

Absorption: Minimal systemic absorption; resulting serum concentration was 0.02% of that achieved with oral formulation

Hypersensitivity to moxifloxacin, other quinolone antibiotics, or any component of the formulation

C

It is not known if moxifloxacin is excreted into breast milk. The manufacturer recommends that caution be exercised when administering moxifloxacin ophthalmic drops to nursing women.

1% to 6%: Ophthalmic: Eye irritation (1% to 2%), conjunctivitis, decreased visual acuity, eye discomfort, eye pain, eye pruritus, lacrimation, ocular hyperemia, subconjunctival hemorrhage, xerophthalmia

Instill 1 drop into affected eye(s) 3 times daily for 7 days