Ascorbic acid deficiency, Burns, Parenteral nutrition, Scurvy prevention and treatment

Vitamin, Water Soluble

Onset of action: 2 days to 3 weeks (Reversal of scurvy symptoms)
Distribution: Pituitary and adrenal glands, leukocytes, eye tissues and humors, and brain, lower concentrations in the plasma and saliva
Metabolism: Reversibly oxidized to dehydroascorbic acid (DHA); both ascorbic acid and DHA are active. Unabsorbed ascorbic acid is degraded in the intestine.
Half-life elimination: 10 hours; Biological half-life: 8 to 40 days
Excretion: Urine (with high serum concentrations)

There are no contraindications listed in the manufacturer's labeling.

C
Animal reproduction studies have not been conducted.

Ascorbic acid is present in breast milk, should consider risk and benefits

Hyperoxaluria (with large doses)

Ascorbic acid deficiency: (IM, IV, SubQ) 70 to 150 mg daily; doses 3 to 5 times the recommended dietary allowance.
Burns: (IM, IV, SubQ) 1 to 2 g daily for severe burns; dose may be determined by extent of tissue injury.
Scurvy: (IM, IV, SubQ) 300 to 1,000 mg daily; dose and duration of therapy should be individualized
Parenteral nutrition: (IV) 200mg/day

1. Mild to severe impairment: No dosage adjustments provided in the manufacturer's labeling. Use with caution.
2. ESRD: 60 to 100 mg once daily is sufficient to prevent serious ascorbate deficiency due to loss from dialysis; doses >100 mg daily may lead to secondary oxalosis and renal oxalate stone formation

There are no dosage adjustments provided in the manufacturer's labeling.
Based on the pharmacokinetics of ascorbic acid, a water-soluble vitamin, a dosage adjustment does not seem necessary.