Elevated intraocular pressure: Reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to topical beta-blockers, prostaglandin analogues, or other IOP-reducing agents and in whom combination therapy is appropriate.

Latanoprost: A prostaglandin F2-alpha analog believed to reduce intraocular pressure by increasing the outflow of the aqueous humor
Timolol: Blocks both beta1- and beta2-adrenergic receptors, reduces intraocular pressure by reducing aqueous humor production or possibly increases the outflow of aqueous humor.

See individual agents.

Hypersensitivity to latanoprost, timolol, benzalkonium chloride, or any component of the formulation; reactive airway disease including severe chronic obstructive pulmonary disease (COPD) and presence or history of bronchial asthma; sinus bradycardia, sick sinus syndrome, sinoatrial block, second- or third-degree atrioventricular block not controlled with pacemaker, overt cardiac failure, cardiogenic shock.

Reproductive studies have not been conducted with this combination. See individual agents.

Timolol has been detected in human breast milk following ophthalmic administration. Latanoprost may enter human breast milk. See individual agents.

>10%:
Ophthalmic: Abnormal eyelash growth (including darkening, lengthening, thickening; 37%), iris hyperpigmentation (2% to 20%; color change due to increase melanin content and is most common in mixed color irises), eye irritation (12%)
1% to 10%:
Cardiovascular: Hypertension (4%), chest pain (1%)
Central nervous system: Depression (2%), headache (2%)
Dermatologic: Dermatological disease (2%), skin rash (1%)
Endocrine & metabolic: Hypercholesterolemia (2%), diabetes mellitus (1%)
Infection: Infection (1%)
Neuromuscular & skeletal: Arthritis (2%), back pain (1%)
Ophthalmic: Ocular hyperemia (7%), visual disturbance (7%), visual field defect (5%), blepharitis (3%), cataract (3%), conjunctivitis (3%), corneal disorder (3%), eye pain (2%), photophobia (2%), error of refraction (2%), conjunctival abnormalities (1%), keratitis (1%)
Respiratory: Upper respiratory tract infection (6%), flu-like symptoms (3%), sinusitis (2%)

Elevated intraocular pressure: Ophthalmic: Instill 1 drop into affected eye(s) once daily