Latanoprost is a phenyl-substituted prostaglandin F2-alpha analogue indicated for the treatment of ocular hypertension and glaucoma.
藥理
Its concomitant use with timolol monotherapy and timolol/dorzolamide combined therapy has significantly reduced intraocular pressure in unresponsive patients, until further data regarding iris pigmentation are available, the drug is recommended only as second-line therapy in patients with persistent increases in intraocular pressure despite optimal doses of other antiglaucoma agents.Latanoprost is a prostaglandin F 2-alpha analog [5]. It is believed to reduce intraocular pressure by increasing the outflow of aqueous humor
藥動學
Latanoprost is a prodrug, and is rapidly hydrolyzed to hydrophilic free acids following ocular instillation.
禁忌症
Hypersensitivity to latanoprost or benzalkonium chloride; use with caution in patient with acute angle-closure, active ocular infection or inflammation, concomitant use in patients with contact lenses; lenses may be reinserted 15 minutes after latanoprost instillation
懷孕分類
C
哺乳分類
Infant risk cannot be ruled out.
副作用
mild conjunctival hyperemia and local irritation, which have been clinically acceptable. Iris pigmentation has been problematic with its long-term use.
劑量和給藥方法
Adults: One drop of a 0.005% ophthalmic solution QD
小兒調整劑量
腎功能調整劑量
肝功能調整劑量
安定性
Store opened bottle at room temperature up to 25 ℃ for six weeks.