【缺藥訊息】 公告日期：2022/11/4。 缺藥品項：懸液粉 Zithromax 600mg 瓶。 缺藥原因：因供應問題缺藥。 替代藥品：國內有同成分同規格藥品可供替代。 配套措施：採購同成分其他規格不同廠藥品 (Azithrom 懸液粉劑 600mg) 替代。 【藥品訊息】 日舒懸液用粉 仿單 日舒懸液用粉 衛教單張

Macrolide類抗生素

Chancroid: Treatment of genital ulcer disease (in men) due to Haemophilus ducreyi
Chronic obstructive pulmonary disease(COPD), acute exacerbation: Acute bacterial exacerbations of COPD due to H. influenzae, M. catarrhalis, or S. pneumoniae
Mycobacterium avium complex(MAC): Prevention of MAC in patients with advanced HIV infection; treatment of disseminated MAC (in combination with ethambutol) in patients with advanced HIV infection
Otitis media, acute: due to H. influenzae, M. catarrhalis, or S. pneumoniae
Pneumonia, community-acquired: CAP due to Chlamydophila pneumoniae, H. influenzae, Legionella pneumophila, M. catarrhalis, Mycoplasma pneumoniae, or S. pneumoniae
Skin and skin structure infection, uncomplicated:due to S. aureus, S. pyogenes, or S. agalactiae
Streptococcal pharyngitis, group A: Treatment of pharyngitis/tonsillitis due to S. pyogenes as an alternative to first-line therapy
Urethritis/cervicitis: due to Chlamydia trachomatis or N. gonorrhoeae Note: CDC treatment guidelines for gonococcal infections only recommend azithromycin (in combination with gentamicin) for uncomplicated gonococcal infection of the cervix or urethra in patients who have a cephalosporin allergy

Antibiotic, Macrolide

1. Hypersensitivity to azithromycin or other macrolide antibiotics
2. Caution in patients with impaired liver function

B; Azithromycin crosses the placenta
Recommended for the treatment of several infections, including chlamydia, gonococcal infections, and Mycobacterium avium complex, and in certain situations prior to vaginal delivery in females at high risk for endocarditis

1. Decreased appetite, diarrhea, rash, and somnolence have been reported; monitor infants for GI disturbances.
2. According to the manufacturer, the decision to breastfeed during therapy should consider the risk and the benefits.

Abdominal pain, diarrhea, and nausea occur in high dose.

General dosing:
5 to 12 mg/kg/dose; typically administered as 10 to 12 mg/kg/dose on day 1 (usual maximum dose: 500 mg/dose) followed by 5 to 6 mg/kg once daily (usual maximum dose: 250 mg/dose)

1. Mild to severe impairment: No dosage adjustment necessary
2. Hemodialysis: No dosage adjustment or supplemental dose necessary
3. Peritoneal dialysis: Minimally dialyzed; No dosage adjustment or supplemental dose necessary
4. CRRT: No dosage adjustment or supplemental dose necessary

Azithromycin is predominantly hepatically eliminated; however, there is no dosage adjustment provided in the manufacturer's labeling.