#特殊劑型：不建議磨粉、管灌藥品 Prevention of calcium and vitamin D deficiency.

Replacement Preparations

Vitamin D3 (cholecalciferol): Absorption: Absorbed in the small intestine; fat soluble Metabolism: Inactive until hydroxylated hepatically to 25-hydroxyvitamin D [25(OH)D; calcifediol] then renally to the active metabolite 1,25-dihydroxyvitamin D (calcitriol). Distribution: Vd/F: Adult: 237 L Half-life, circulating: 25(OH)D: 2 to 3 weeks; 1,25-dihydroxyvitamin D: ~4 hours. Excretion: Feces

Pregnancy Considerations The cholecalciferol metabolite, 25(OH)D, crosses the placenta; maternal serum concentrations correlate with fetal concentrations at birth Adequate maternal vitamin D is required for fetal growth and development. Vitamin D deficiency in a pregnant woman may lead to a vitamin D deficiency in the neonate . Serum 25(OH)D concentrations should be measured in pregnant women considered to be at increased risk of deficiency . The amount of vitamin D contained in prenatal vitamins may not be adequate to treat a deficiency during pregnancy; although larger doses may be needed, current guidelines recommend a total of 25 to 50 mcg/day (1,000 to 2,000 units/day) until more safety data is available (ACOG 2011). In women not at risk for deficiency, doses larger than the RDA should be avoided during pregnancy .

Breastfeeding Considerations Cholecalciferol is present in breast milk Following administration of vitamin D as cholecalciferol, concentrations of cholecalciferol and 25(OH)D increase in the maternal serum and may correlate with breast milk concentrations

Calcium: Nephrolithiasis,Cardiovascular disease, dyspepsia and constipation Vitamin D : hypercalcemia, hypercalciuria, and kidney stones.

Take one tablet at a time, 2–3 times daily after meals, and chew thoroughly before swallowing.

Store below 25°C